Conserved catalytic motifs encode enzyme-like supramolecular peptide assemblies — UCSF

A seven-residue fragment derived from the active site of carbonic anhydrase spontaneously forms Zn²⁺-binding amyloid fibrils that catalyze carbon dioxide hydration with catalytic efficiencies surpassing previous carbonic anhydrase mimics and approaching those of natural enzymes. Cryo-electron ...